The glycocalyx has multiple functions it mediates nitric oxide synthesis and superoxide dysmutation acts as a protective sieving barrier inhibits platelet adherence and coagulation and it regulates inflammation by preventing leukocyte adhesion to the vessel walls. Note citations are based on reference standards however formatting rules can vary widely between applications and fields of interest or study the specific requirements or preferences of your reviewing publisher classroom teacher institution or organization should be applied. Endothelial glycocalyx novel insight into atherosclerosis ye zeng the evidence shows that endothelial glycocalyx exerts an important role in inflammation and atherosclerosis we previously demonstrated that hydrodynamic force such as shear stress induces the remodeling of the major component of glycocalyx including glypican 1 with . The role of the endothelial glycocalyx in the pathogenesis of atherosclerosis a new frontier in cardiovascular health derrick desilva jr md jeffrey gladden md facc chen chen phd jon ward ma much recent work on the pathogenesis of atherosclerosis has focused on the response to injury theory. Regulation and function of endothelial glycocalyx layer in vascular diseases with specific emphasis on its remodelling in inflammatory vascular diseases and discusses its potential as a novel therapeutic target to treat vascular pathologies a potential role in the pathogenesis of atherosclerosis
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