Genome duplication events generate a duplicate for every gene in the genome representing a huge opportunity for a step change in organismal complexity however genome duplication presents significant problems for the faithful transmission of a genome from one generation to the next and is consequently a rare event at least in metazoa. In addition to gene duplication whole scale genome duplication polyploidization has been a major source of gene duplicates the main mechanisms by which polyploidization is achieved have recently been reviewed by ramsey and schemske 1998. 17q12 duplication is a chromosomal change in which a small piece of chromosome 17 is copied duplicated abnormally in each cellthe duplication occurs on the long q arm of the chromosome at a position designated q12 signs and symptoms related to 17q12 duplications vary significantly even among members of the same family
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